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Meta-Analysis
. 2009 May;60(5):1250-4.
doi: 10.1002/art.24468.

The PRL -1149 G/T polymorphism and rheumatoid arthritis susceptibility

Yvonne C Lee  1 , Soumya Raychaudhuri, Jing Cui, Immaculata De Vivo, Bo Ding, Lars Alfredsson, Leonid Padyukov, Karen H Costenbader, Mark Seielstad, Robert R Graham, Lars Klareskog, Peter K Gregersen, Robert M Plenge, Elizabeth W Karlson
Affiliations
Meta-Analysis

The PRL -1149 G/T polymorphism and rheumatoid arthritis susceptibility

Yvonne C Lee et al. Arthritis Rheum. 2009 May.

Abstract

Objective: Previous studies have demonstrated that the PRL -1149 T (minor) allele decreases prolactin expression and may be associated with autoimmune disease. The aim of this study was to determine the role of the PRL -1149 G/T polymorphism (rs1341239) in rheumatoid arthritis (RA) susceptibility.

Methods: We examined the association between PRL -1149 G/T and RA risk in 4 separate study populations, consisting of a total of 3,405 RA cases and 4,111 controls of self-reported white European ancestry. Samples were genotyped using 1 of 3 genotyping platforms, and strict quality control metrics were applied. We tested for association using a 2-tailed Cochran-Mantel-Haenszel additive, fixed-effects model.

Results: In the individual populations, odds ratios (ORs) for an association between PRL -1149 T and RA risk ranged from 0.80 to 0.97. In a joint meta-analysis across all 4 populations, the OR for an association between PRL -1149 T and RA risk was 0.90 (95% confidence interval 0.84-0.96, P=0.001).

Conclusion: Our findings indicate a possible association between the PRL -1149 T allele and decreased RA risk. The effect size is small but similar to ORs for other genetic polymorphisms associated with complex traits, including RA.

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Figures

Figure 1
Figure 1. Association of PRL -1149 T across four collections
For each collection, we plot the odds ratio (diamond) and the 95% confidence interval. A dashed line indicates the odds ratio across all four collections.
See this image and copyright information in PMC

References

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