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Comparative Study
. 2009;33(1):55-65.
doi: 10.1159/000215830. Epub 2009 Apr 28.

Using telephone and informant assessments to estimate missing Modified Mini-Mental State Exam scores and rates of cognitive decline. The cardiovascular health study

Alice M Arnold  1 , Anne B Newman, Norma Dermond, Mary Haan, Annette Fitzpatrick
Affiliations
Comparative Study

Using telephone and informant assessments to estimate missing Modified Mini-Mental State Exam scores and rates of cognitive decline. The cardiovascular health study

Alice M Arnold et al. Neuroepidemiology. 2009.

Abstract

Aim: To estimate an equivalent to the Modified Mini-Mental State Exam (3MSE), and to compare changes in the 3MSE with and without the estimated scores.

Methods: Comparability study on a subset of 405 participants, aged >or=70 years, from the Cardiovascular Health Study (CHS), a longitudinal study in 4 United States communities. The 3MSE, the Telephone Interview for Cognitive Status (TICS) and the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) were administered within 30 days of one another. Regression models were developed to predict the 3MSE score from the TICS and/or IQCODE, and the predicted values were used to estimate missing 3MSE scores in longitudinal follow-up of 4,274 CHS participants.

Results: The TICS explained 67% of the variability in 3MSE scores, with a correlation of 0.82 between predicted and observed scores. The IQCODE alone was not a good estimate of 3MSE score, but improved the model fit when added to the TICS model. Using estimated 3MSE scores classified more participants with low cognition, and rates of decline were greater than when only the observed 3MSE scores were considered.

Conclusions: 3MSE scores can be reliably estimated from the TICS, with or without the IQCODE. Incorporating these estimates captured more cognitive decline in older adults.

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Figures

Fig. 1.
Fig. 1.
3MSE and TICS score in validation sample. a Observed scores with fitted regression line. b Observed and predicted scores.
Fig. 2.
Fig. 2.
ROC curves for predicting 3MSE ≥ 80 from TICS score, IQCODE score or both.
Fig. 3.
Fig. 3.
3MSE and IQCODE in validation sample. a Observed scores with fitted regression line. b Observed and predicted scores.
Fig. 4.
Fig. 4.
3MSE observed and predicted scores from both TICS and IQCODE in the full sample.
Fig. 5.
Fig. 5.
Regression of 3MSE on study year for observed values (solid line), adding TICS (dashed line) and then adding IQCODE (dotted line), with confidence bands at selected points.
Fig. 6.
Fig. 6.
Annual rate of change in 3MSE by IQCODE.
See this image and copyright information in PMC

References

    1. Hebert LE, Beckett LA, Scherr PA, et al. Annual incidence of Alzheimer disease in the United States projected to the years 2000 through 2050. Alzheimer Dis Alloc Disord. 2001;15:169–173. - PubMed
    1. DiBari M, Williamson J, Pahor M. Missing-data in epidemiological studies of age-associated cognitive decline. J Am Geriatric Soc. 1999;47:1380–1381. - PubMed
    1. Brayne C, Spiegelhalter DJ, Dufouil C, et al. Estimating the true extent of cognitive decline in the old. J Am Geriatric Soc. 1999;47:1283–1288. - PubMed
    1. Anstey KJ, Luszcz MA. Selective non-response to clinical assessment in the longitudinal study of aging: implications for estimating population levels of cognitive function and dementia. Int J Geriatr Psychiatry. 2002;17:704–709. - PubMed
    1. Brandt J, Spence M, Folstein M. The Telephone Interview for Cognitive Status. Neuropsychiat Neuropsychol Behav Neurol. 1988;1:111–117.

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