Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 May 2:1:10.
doi: 10.1186/1758-3284-1-10.

Correlation of histopathological diagnosis with habits and clinical findings in oral submucous fibrosis

Shruti Pandya  1 , Ajay Kumar Chaudhary, Mamta Singh, Mangal Singh, Ravi Mehrotra
Affiliations

Correlation of histopathological diagnosis with habits and clinical findings in oral submucous fibrosis

Shruti Pandya et al. Head Neck Oncol. .

Abstract

Background: Oral submucous fibrosis is a common oral health problem in India. This study was conducted to correlate the histopathological diagnosis with habits and clinical findings in patients suffering from oral submucous fibrosis (OSF).

Methods: Patients suffering from oral submucous fibrosis from the Departments of Otorhinolaryngology and Pathology, Moti Lal Nehru Medical College, Allahabad, India were studied from 2004-2008. Detailed information was gathered in a pretested proforma. Emphasis was given to the various addictions, clinical findings and histological examination was done.

Results: Two hundred and thirty nine patients were studied, yielding a male to female ratio of 6.8:1. Maximum patients were in the 21-30 years age group with a marked male predominance. Of these, 197 (82.4%) patients chewed areca nut/dohra, 14 (5.8%) were smokers and 2 (0.8%) patients were habituated to alcohol. 89 (37.2%) patients reported difficulty in opening of the mouth (trismus). 51 (57.4%) patients were found to have stage II (2-3 cm) trismus while rest had stage I and III. The buccal mucosa was found to be the most commonly involved site. On the basis of histopathological examination, 52 (21.7%) were classified as OSF grade I, 75 (31.3%) patients as grade II and 112 (46.8%) had grade III disease.

Conclusion: The widespread habit of chewing dohra/paan masala is a major risk factor of OSF, especially in the younger age group. In this study, an increase in histopathological grading was found with severity and duration of addiction habit. However no significant correlation was found between clinical staging and histopathological grading.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Distribution of 239 cases of OSF according to age & sex.
Figure 2
Figure 2
Sites of fibrosis.
Figure 3
Figure 3
Gender wise distribution of patients with their clinical symptoms.
Figure 4
Figure 4
Oral mucosa showing OSF grade II demonstrating fibroblasts in the juxta-epithelial area with dilated blood vessels (H and E ×100).
Figure 5
Figure 5
Oral Mucosa showing OSF grade III showing thinning of the epidermis, hyalinized collagen and lymphocytic infiltration. (H and E × 400).
Figure 6
Figure 6
Paan quids being served at a wedding reception.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Tilakratne WM, Klinikowski MF, Saku T, Peters TJ, Warnakulasuriya S. Oral submucous fibrosis: Review on aetiology and pathogenesis. Oral Oncol. 2005;30:30–32. - PubMed
    1. Sinor PN, Gupta PC, Murti PR, Bhonsle RB, Daftary DK, Mehta FS. A case-control study of oral submucous fibrosis with special reference to the aetiologic role of areca nut. J Oral Pathol Med. 1990;19:94–98. doi: 10.1111/j.1600-0714.1990.tb00804.x. - DOI - PubMed
    1. Lai DR, Chen HR, Lin LM, Huang YL, Tsai CC. Clinical evaluation of different treatment methods for oral submucous fibrosis. A 10-year experience with 150 cases. J Oral Pathol Med. 1995;24:402–6. doi: 10.1111/j.1600-0714.1995.tb01209.x. - DOI - PubMed
    1. Rajalalitha P, Vali S. Molecular pathogenesis of oral submucous fibrosis-a collagen metabolic disorder. J Oral Pathol Med. 2005;34:321–28. doi: 10.1111/j.1600-0714.2005.00325.x. - DOI - PubMed
    1. Mehrotra R, Pandya S, Chaudhary AK, Kumar M, Singh M. Prevalence of oral premalignant and malignant lesions at a tertiary level hospital in Allahabad, India. Asian Pac J Cancer Prev . 2008;9:263–265. - PubMed

LinkOut - more resources