Comment
doi: 10.1016/j.neuron.2009.04.010.
A lethal convergence of dopamine and calcium
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- PMID: 19409260
- DOI: 10.1016/j.neuron.2009.04.010
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Comment
A lethal convergence of dopamine and calcium
Neuron.
.
Free article
Abstract
The controversy about whether dopamine contributes to cell loss in Parkinson's disease takes a new turn as Mosharov et al. in this issue of Neuron demonstrate that Ca2+ influx through L-type channels elevates dopamine synthesis to potentially toxic levels in vulnerable ventral mesencephalon neurons.
Comment on
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Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons.Neuron. 2009 Apr 30;62(2):218-29. doi: 10.1016/j.neuron.2009.01.033. Neuron. 2009. PMID: 19409267 Free PMC article.
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