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Guideline
. 1991 Aug;54(8):683-8.
doi: 10.1136/jnnp.54.8.683.

Magnetic resonance imaging in monitoring the treatment of multiple sclerosis: concerted action guidelines

D H Miller  1 , F Barkhof, I Berry, L Kappos, G Scotti, A J Thompson
Affiliations
Guideline

Magnetic resonance imaging in monitoring the treatment of multiple sclerosis: concerted action guidelines

D H Miller et al. J Neurol Neurosurg Psychiatry. 1991 Aug.

Abstract

Serial gadolinium enhanced MRI of the brain detects much clinically silent disease activity in early relapsing-remitting and secondary progressive multiple sclerosis (MS), and thus has an important role in monitoring the effects of therapy. Based on the proceedings of a recent Commission of the European Communities (CEC) workshop and a review of the literature, guidelines are presented for using MRI to monitor treatment trials in MS. The guidelines consider: A) MRI system and techniques; B) patient selection; C) trial design; D) analysis of results. Priorities for future research are also indicated.

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