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. 1991 Aug;54(8):722-5.
doi: 10.1136/jnnp.54.8.722.

Platinum-based chemotherapy for recurrent CNS tumours in young patients

E Douek  1 , J E Kingston, J S Malpas, P N Plowman
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Platinum-based chemotherapy for recurrent CNS tumours in young patients

E Douek et al. J Neurol Neurosurg Psychiatry. 1991 Aug.

Abstract

Twenty nine patients (median age 12 years) with a CNS tumour, received platinum-based chemotherapy for assessable disease. In 23 patients there was an objective response with improvement lasting for a median duration of 11 months. There was little difference in the response to cisplatinum or carboplatin therapy. The response rates in specific disease groups were: medulloblastoma 8/10, two with a complete response (CR) and six with a partial response (PR); ependymoma 1/5 PR; pineal retinoblastoma 5/5 with three CR and two PR; primitive neurectodermal tumours (PNET) 2/2 PR and pineal germ cell tumours 6/6 with four CR and two PR. It is concluded that platinum-based chemotherapy has a beneficial effect on CNS tumours of the CNS, especially medulloblastoma, ectopic intracranial retino-blastoma and pineal germ cell tumours.

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