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Comment
. 2009 May 5;15(5):355-7.
doi: 10.1016/j.ccr.2009.04.003.

Inflamed snail speeds metastasis

Chih-Cheng Yang  1 , Dieter A Wolf
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Inflamed snail speeds metastasis

Chih-Cheng Yang et al. Cancer Cell. .
Free article

Abstract

Macrophage infiltration and inflammatory cytokines are powerful drivers of tumorigenesis and metastasis. Wu et al., in this issue of Cancer Cell, show that TNFalpha-dependent NFkappaB activation induces COP9 signalosome-mediated inhibition of GSK3beta and the SCF(beta-TRCP) ubiquitin ligase, thus leading to stabilization of the transcription factor Snail and promoting cell migration and metastasis.

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