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. 2009 Aug;136(2):396-404.
doi: 10.1378/chest.08-2858. Epub 2009 May 1.

CT metrics of airway disease and emphysema in severe COPD

Woo Jin Kim  1 , Edwin K Silverman  2 , Eric Hoffman  3 , Gerard J Criner  4 , Zab Mosenifar  5 , Frank C Sciurba  6 , Barry J Make  7 , Vincent Carey  8 , Raúl San José Estépar  9 , Alejandro Diaz  10 , John J Reilly  6 , Fernando J Martinez  11 , George R Washko  12 ; NETT Research Group
Affiliations

CT metrics of airway disease and emphysema in severe COPD

Woo Jin Kim et al. Chest. 2009 Aug.

Abstract

Background: CT scan measures of emphysema and airway disease have been correlated with lung function in cohorts of subjects with a range of COPD severity. The contribution of CT scan-assessed airway disease to objective measures of lung function and respiratory symptoms such as dyspnea in severe emphysema is less clear.

Methods: Using data from 338 subjects in the National Emphysema Treatment Trial (NETT) Genetics Ancillary Study, densitometric measures of emphysema using a threshold of -950 Hounsfield units (%LAA-950) and airway wall phenotypes of the wall thickness (WT) and the square root of wall area (SRWA) of a 10-mm luminal perimeter airway were calculated for each subject. Linear regression analysis was performed for outcome variables FEV(1) and percent predicted value of FEV(1) with CT scan measures of emphysema and airway disease.

Results: In univariate analysis, there were significant negative correlations between %LAA-950 and both the WT (r = -0.28, p = 0.0001) and SRWA (r = -0.19, p = 0.0008). Airway wall thickness was weakly but significantly correlated with postbronchodilator FEV(1)% predicted (R = -0.12, p = 0.02). Multivariate analysis showed significant associations between either WT or SRWA (beta = -5.2, p = 0.009; beta = -2.6, p = 0.008, respectively) and %LAA-950 (beta = -10.6, p = 0.03) with the postbronchodilator FEV(1)% predicted. Male subjects exhibited significantly thicker airway wall phenotypes (p = 0.007 for WT and p = 0.0006 for SRWA).

Conclusions: Airway disease and emphysema detected by CT scanning are inversely related in patients with severe COPD. Airway wall phenotypes were influenced by gender and associated with lung function in subjects with severe emphysema.

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Figures

Figure 1
Figure 1
Relationship of %LAA and BMI.
Figure 2
Figure 2
Relationship of the %LAA and SRWA Pi10 mm.
See this image and copyright information in PMC

References

    1. Rabe KF, Hurd S, Anzueto A, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med. 2007;176:532–555. - PubMed
    1. Hogg JC. Pathophysiology of airflow limitation in chronic obstructive pulmonary disease. Lancet. 2004;364:709. - PubMed
    1. de Jong PA, Muller NL, Pare PD, et al. Computed tomographic imaging of the airways: relationship to structure and function. Eur Respir J. 2005;26:140–152. - PubMed
    1. Nakano Y, Muro S, Sakai H, et al. Computed tomographic measurements of airway dimensions and emphysema in smokers: correlation with lung function. Am J Respir Crit Care Med. 2000;162:1102–1108. - PubMed
    1. Hasegawa M, Nasuhara Y, Onodera Y, et al. Airflow limitation and airway dimensions in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2006;173:1309–1315. - PubMed

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