Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Jun 15;8(12):1966-7.
doi: 10.4161/cc.8.12.8708. Epub 2009 Jun 9.

A novel mode of FoxM1 regulation: positive auto-regulatory loop

Marianna Halasi  1 , Andrei L Gartel
Affiliations

A novel mode of FoxM1 regulation: positive auto-regulatory loop

Marianna Halasi et al. Cell Cycle. .

Abstract

Oncogenic transcription factor FoxM1 represents an attractive therapeutic target in the fight against cancer, because it is overexpressed in a majority of human tumors. Previously, we identified the thiazole antibiotics as potent inhibitors of FoxM1. Surprisingly, investigation of the mechanism of action of FoxM1 inhibitors revealed a novel mode of positive auto-regulation of FoxM1.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources