doi: 10.2174/138920207783591681.
Incomplete coverage of candidate genes: a poorly considered bias
Affiliations
- PMID: 19412419
- PMCID: PMC2647155
- DOI: 10.2174/138920207783591681
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Incomplete coverage of candidate genes: a poorly considered bias
Curr Genomics.
2007 Nov.
Abstract
Current genetic investigations are performed both on the basis of a rational and biologically based choice of candidate genes and through genome wide scans. Nonetheless, lack of replication is a common problem in psychiatric genetics as well as in other genetic fields. There are a number of reasons for this inconsistency, among them a well known but poorly considered issue is gene coverage. The aim of the present paper is to focus on this well known and defectively deemed bias, especially when a candidate gene approach is chosen. The rational and the technical feasibility of this proposal are discussed as well as a survey of current investigations. The known consistent methodology to fix this bias is also discussed.
Keywords: Candidate genes; association studies; methodology.; psychiatry genetics.
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