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. 2006 Mar;2(1):105-10.

Neuropsychiatric symptoms as a predictor of caregiver burden in Alzheimer's disease

Ricardo F Allegri  1 , Diego Sarasola, Cecilia M Serrano, Fernando E Taragano, Raúl L Arizaga, Judith Butman, Leandro Loñ
Affiliations

Neuropsychiatric symptoms as a predictor of caregiver burden in Alzheimer's disease

Ricardo F Allegri et al. Neuropsychiatr Dis Treat. 2006 Mar.

Abstract

Aims: Patients with Alzheimer's disease need assistance and supervision of their daily activities. They survive for protracted periods of time, placing an extensive burden of care on the caregiver prior to the patient's death. The present study addressed the predictive value of behavior-related burden on Alzheimer's disease caregivers.

Participants: 82 patients with probable Alzheimer's (73.7 +/- 8.1 years), and their primary caregivers (59.6 +/- 14.8 years, 81.5% women), were assessed.

Methods: Cognitive impairment, neuropsychiatric symptoms, and dementia severity were assessed with Mini Mental State Examination (MMSE), Neuropsychiatric Inventory (NPI), and Clinical Dementia Rating (CDR), respectively. Caregivers were given Zarit's Burden Interview and Carer Activity Inventory.

Results: Neuropsychiatric symptoms like delusions, hallucinations, restlessness, anxiety, euphoria, disinhibition, unusual motor behavior, sleep disturbances, and appetite alterations were the best caregiver burden predictors (NPI r = 0.482, p < 0.001). No correlation with cognition, disease stage, or negative neuropsychiatric symptoms (depression and apathy) was found.

Conclusion: Increased caregiver burden was related to increased levels of patient behavioral disturbance. Of these symptoms, hallucinations, unusual (motor) behavior, and abnormal behavior at nighttime were the most significant. No correlation with neuropsychiatric symptoms such as apathy and depression was found. This may have relevance to appropriate interventions for caregivers.

Keywords: Alzheimer’s; behavior; caregiver burden; caregivers; neuropsychiatric.

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Figures

Figure 1
Figure 1
Patient’s neuropsychiatric symptoms (percentage of subjects with symptoms).
See this image and copyright information in PMC

References

    1. Absher JR, Cummings JL. Cognitive and noncognitive aspects of dementia syndromes: an overview. In: Burns A, Levy R, editors. Dementia . London: Chapman & Hall Medical; 1994.
    1. Allegri RF, Ollari JA, Mangone CA, et al. El “Mini Mental State Examination” en la Argentina: Instrucciones para su administración. [“Mini Mental State Examination” in Argentina. Instructions for its use] Rev Neurol Argent. 1999;24:31–5.
    1. [APA] American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: APA; 1994.
    1. Annerstedt L, Elmstahl S, Ingvad B, et al. Family caregiving in dementia, an analysis of the caregiver’s burden and the “breaking-point” when home care becomes inadequate. Scand J Public Health. 2000;28:23–31. - PubMed
    1. Arguelles S, Loewenstein DA, Eisdorfer C, et al. Caregivers’ judgments of the functional abilities of the Alzheimer‘s disease patient: impact of caregivers’ depression and perceived burden. J Geriatr Psychiatry Neurol. 2001;14:91–8. - PubMed

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