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. 2009;28(3):300-11.
doi: 10.1080/10641950802601237.

Preeclampsia is associated with lower percentages of regulatory T cells in maternal blood

Jelmer R Prins  1 , Hendrik M Boelens, Janneke Heimweg, Sicco Van der Heide, Anthony E Dubois, Antoon J Van Oosterhout, Jan Jaap H M Erwich
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Free article

Preeclampsia is associated with lower percentages of regulatory T cells in maternal blood

Jelmer R Prins et al. Hypertens Pregnancy. 2009.
Free article

Abstract

Objective: Immunological mechanisms are involved in the pathophysiology of preeclampsia. During pregnancy there is an increase in regulatory T (Treg) cells, which has an important role in regulating tolerance to the immunologically distinct fetus. We hypothesised that percentages of Treg cells are decreased in preeclamptic patients.

Methods: Peripheral blood was obtained from 26 healthy pregnant controls and 18 preeclamptic patients. Treg cells were measured using flow-cytometry.

Results: Women with pregnancies complicated by preeclampsia had significantly lower percentages of CD4(+)FOXP3(+) Treg cells.

Conclusion: We conclude that a deficiency of regulatory T cells may play a role in the pathophysiology of preeclampsia.

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