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. 2009 May 27;131(20):6898-9.
doi: 10.1021/ja900046z.

Ruthenium-catalyzed carbonylation at ortho C-H bonds in aromatic amides leading to phthalimides: C-H bond activation utilizing a bidentate system

Satoshi Inoue  1 , Hirotaka Shiota, Yoshiya Fukumoto, Naoto Chatani
Affiliations

Ruthenium-catalyzed carbonylation at ortho C-H bonds in aromatic amides leading to phthalimides: C-H bond activation utilizing a bidentate system

Satoshi Inoue et al. J Am Chem Soc. .

Abstract

A new type of carbonylation of the ortho C-H bonds in aromatic amides 1, in which the pyridin-2-ylmethylamino moiety functions as a bidentate directing group, can be achieved. The presence of ethylene as a hydrogen acceptor and also of H(2)O, probably for the generation of an active catalytic species, is required. A wide variety of functional groups, including methoxy, amino, ester, ketone, cyano, chloro, and even bromo substituents, can be substituted for aromatic amides. The complex 9 was isolated by the stoichiometric reaction of 1b and Ru(3)(CO)(12), in which 1b binds to one Ru atom in the expected N,N fashion and the carbonyl oxygen binds to the other Ru atom as an O donor.

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