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. 2009 Dec;16(12):895-6.
doi: 10.1111/j.1365-2893.2009.01138.x. Epub 2009 Apr 27.

Lack of hepatitis E virus infection in HIV patients with advanced immunodeficiency or idiopathic liver enzyme elevations

A Madejón  1 , E Vispo, M Bottecchia, M Sánchez-Carrillo, J García-Samaniego, V Soriano
Affiliations

Lack of hepatitis E virus infection in HIV patients with advanced immunodeficiency or idiopathic liver enzyme elevations

A Madejón et al. J Viral Hepat. 2009 Dec.

Abstract

Hepatitis E virus (HEV) is an enterically transmissible RNA agent that causes self-limited acute hepatitis. Recent reports have highlighted that organ-transplant recipients may develop chronic hepatitis E and progress to cirrhosis. Similar cases could occur in HIV patients. We have investigated 50 HIV-infected individuals with CD4 counts <200 cells/mm(3) and 43 with cryptogenic hepatitis. None of them showed HEV viremia. Thus, HEV infection does not seem to be prevalent in the HIV population and accordingly universal HEV vaccination is not warranted in these patients.

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