doi: 10.1038/266815a0.
Defective interfering particles with covalently linked [+/-]RNA induce interferon
- PMID: 194158
- DOI: 10.1038/266815a0
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Defective interfering particles with covalently linked [+/-]RNA induce interferon
Nature.
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Abstract
Defective interfering (DI) particles of vesicular stomatitis virus which contain covalently linked complementary [+]message and [-]anti-message RNA as a single-stranded ribonucleoprotein complex within the particle, are extremely efficient inducers of interferon. A single particle can induce a quantum yield of interferon. A single molecule of double-stranded RNA presumed to form, at least in part, on entry into the cell is thought to induce interferon synthesis. Conventional [-]RNA DI particles with the same polypeptide composition as [+/-]RNA DI particles fail to induce interferon.
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