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Review
. 2009:38:371-83.
doi: 10.1146/annurev.biophys.050708.133740.

Lessons from structural genomics

Thomas C Terwilliger  1 , David Stuart, Shigeyuki Yokoyama
Affiliations
Review

Lessons from structural genomics

Thomas C Terwilliger et al. Annu Rev Biophys. 2009.

Abstract

A decade of structural genomics, the large-scale determination of protein structures, has generated a wealth of data and many important lessons for structural biology and for future large-scale projects. These lessons include a confirmation that it is possible to construct large-scale facilities that can determine the structures of a hundred or more proteins per year, that these structures can be of high quality, and that these structures can have an important impact. Technology development has played a critical role in structural genomics, the difficulties at each step of determining a structure of a particular protein can be quantified, and validation of technologies is nearly as important as the technologies themselves. Finally, rapid deposition of data in public databases has increased the impact and usefulness of the data and international cooperation has advanced the field and improved data sharing.

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Figures

Figure 1
Figure 1
PDB depositions by NIH Protein Structure Initiative Large-Scale Centers (see http://www.mcsg.anl.gov for a current plot).
See this image and copyright information in PMC

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