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Comment
. 2009 Apr 28;106(17):6887-8.
doi: 10.1073/pnas.0903024106. Epub 2009 Apr 22.

Amplification of signaling via cellular allosteric relay and protein disorder

Buyong Ma  1 , Ruth Nussinov
Affiliations
Comment

Amplification of signaling via cellular allosteric relay and protein disorder

Buyong Ma et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Nanoscale allosteric signal transduction relay from the cell surface to the nucleus. (A) Allosteric proteins and cell signaling. The simplified GPCR-cAMP-CRP and GPCR-cAMP-PKA-CREB pathways represent short routes connecting extracellular stimuli to the nucleus via the cytoplasm. Cytoplasmic proteins often display an on/off transmission switch, like the PKA and scaffold MAPK systems. (B) Allosteric relay in signal transduction can be nanoscale, over hundreds of nanometers.
See this image and copyright information in PMC

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References

    1. Changeux JP, Edelstein SJ. Allosteric mechanisms of signal transduction. Science. 2005;308:1424–1428. - PubMed
    1. Cui Q, Karplus M. Allostery and cooperativity revisited. Protein Sci. 2008;17:1295–1307. - PMC - PubMed
    1. Goodey NM, Benkovic SJ. Allosteric regulation and catalysis emerge via a common route. Nat Chem Biol. 2008;4:474–482. - PubMed
    1. Tsai CJ, Del Sol A, Nussinov R. Protein allostery, signal transmission and dynamics: A classification scheme of allosteric mechanisms. Mol Biosyst. 2009;5:207–216. - PMC - PubMed
    1. Gunasekaran K, Ma B, Nussinov R. Is allostery an intrinsic property of all dynamic proteins? Proteins. 2004;57:433–443. - PubMed

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