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Comment
. 2009 Apr 28;106(17):6889-90.
doi: 10.1073/pnas.0902770106. Epub 2009 Apr 22.

TLR2-mediated neutrophil depletion exacerbates bacterial sepsis

Thierry Roger  1 , Thierry Calandra
Affiliations
Comment

TLR2-mediated neutrophil depletion exacerbates bacterial sepsis

Thierry Roger et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Effect of a low or a high inoculum of L. monocytogenes on neutrophil. Bacteria interacts with pattern-recognition receptor (PRR) expressed by innate immune and bone marrow stromal cells to induce production of G-CSF, chemokines, and cytokines, resulting in granulopoiesis and neutrophil activation. Bacterial sepsis is known to augment the lifespan of neutrophils. Navarini et al. (7) showed that infection with a low L. monocytogenes inoculum augmented the lifespan of neutrophils, resulting in the clearance of bacterial infection and survival of mice. By contrast, infection with a high L. monocytogenes inoculum caused apoptosis of neutrophils, rapid bone marrow depletion, proliferation of bacteria in liver and spleen, dissemination into the blood stream, and death.
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