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. 2009 Apr;14(2):147-52.
doi: 10.1111/j.1542-474X.2009.00289.x.

Familial aggregation and heritability of electrocardiographic intervals and heart rate in a rural Chinese population

Jianping Li  1 , Yong Huo, Yan Zhang, Zhian Fang, Jianhua Yang, Tonghua Zang, Xiping Xu, Xin Xu
Affiliations

Familial aggregation and heritability of electrocardiographic intervals and heart rate in a rural Chinese population

Jianping Li et al. Ann Noninvasive Electrocardiol. 2009 Apr.

Abstract

Background: Estimates of the genetic influences on electrocardiographic (ECG) parameters are inconsistent in previous reports, and no such studies have been performed in China. So we estimated genetic contributions to PR and QRS intervals and the rate-adjusted QT interval (Bazett's QTc) in a Chinese rural population.

Methods: A total of 2909 subjects from 847 families were enrolled in the current study. Genetic contributions to ECG parameters were estimated in two ways: correlation coefficients among family members (father-mother, parent-offspring, first sibling-other sibling) and the heritability of each of the ECG parameters.

Results: Our results showed significant correlations among family members on theses parameters: the correlation coefficients for PR interval, QRS duration, QTc interval, and HR, between parent-sibling, and sibling-sibling were 0.17 and 0.13, 0.18 and 0.23, 0.22 and 0.28, 0.19 and 0.18, respectively. The heritability for PR interval, QRS duration, QTc interval, and HR were estimated as 0.34, 0.43, 0.40, and 0.34, respectively.

Conclusion: Genetic factors, together with the environmental and other cofactors contribute no more than 60% to the variance of the ECG intervals, supporting the concept that multiple factors, including gene-gene and gene-environment interactions could influence ECG interval phenotypes, and genetic factors play a major role.

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References

    1. Murkofsky RL, Dangas G, Diamond JA, et al A prolonged QRS duration on surface electrocardiogram is a specific indicator of left ventricular dysfunction. J Am Coll Cardiol 1998;32:476–482. - PubMed
    1. Shamim W, Yousufuddin M, Cicoria M, et al Incremental changes in QRS duration in serial ECGs over time identify high risk elderly patients with heart failure. Heart 2002;88:47–51. - PMC - PubMed
    1. Xiao HB, Roy C, Fujimoto S, et al Natural history of abnormal conduction and its relation to prognosis in patients with dilated cardiomyopathy. Int J Cardiol 1996;53:163–170. - PubMed
    1. Peters RW, Byington RP, Barker A, et al Prognostic value of prolonged ventricular repolarization following myocardial infarction: The BHAT experience. J Clin Epidemil 1990;43:167–172. - PubMed
    1. Algra A, Tijssen JGP, Roelandt JRTC, et al QTc prolongation measured by standard 12‐ lead electrocardiography is an independent risk factor for sudden death due to cardiac arrest. Circulation 1991;83:1888–1894. - PubMed

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