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Review
. 2009 Jun;19(3):254-65.
doi: 10.1016/j.gde.2009.03.008. Epub 2009 May 4.

The genetics of Parkinson's syndromes: a critical review

John Hardy  1 , Patrick Lewis, Tamas Revesz, Andrew Lees, Coro Paisan-Ruiz
Affiliations
Review

The genetics of Parkinson's syndromes: a critical review

John Hardy et al. Curr Opin Genet Dev. 2009 Jun.

Abstract

Genetic analysis has identified many loci designated as PARK loci (OMIM #168600). Many of these loci do not refer to idiopathic Parkinson's disease which is characterized by Lewy body pathology, but rather to clinical parkinsonisms. In this review, besides reviewing the genetic of the disorder, we argue that this designation is misleading and that if we seek to understand the pathogenesis, we should study the genetics of Lewy body diseases: these include not only idiopathic Parkinson's disease, but also such disparate syndromes as Hallevorden-Spatz disease and Niemann-Pick Type C.

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