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. 2009 Jul;47(7):2349-50.
doi: 10.1128/JCM.00799-09. Epub 2009 May 6.

Novel Clostridium botulinum toxin gene arrangement with subtype A5 and partial subtype B3 botulinum neurotoxin genes

Nir Dover, Jason R Barash, Stephen S Arnon

Novel Clostridium botulinum toxin gene arrangement with subtype A5 and partial subtype B3 botulinum neurotoxin genes

Nir Dover et al. J Clin Microbiol. 2009 Jul.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Arrangement of the IBCA94-0216 botulism neurotoxin gene cluster. The IBCA94-0216 partial bont/B sequence begins at what would be base pair position 1362 in the intact type B neurotoxin gene, and it continues downstream for an additional 2,514 bp to the 3′ end of the neurotoxin gene. The missing 5′ 1,361 bp of the bont/B gene (which would code for the neurotoxin light chain), as well as any second cluster of accessory genes, could not be found by extensive PCR testing. The prime symbol designates a partial gene.
See this image and copyright information in PMC

References

    1. Arnon, S. S., R. Schechter, T. V. Inglesby, D. A. Henderson, J. G. Bartlett, M. S. Ascher, E. Eitzen, A. D. Fine, J. Hauer, M. Layton, S. Lillibridge, M. T. Osterholm, T. O'Toole, G. Parker, T. M. Perl, P. K. Russell, D. L. Swerdlow, K. Tonat, and the Working Group on Civilian Biodefense. 2001. Botulinum toxin as a biological weapon: medical and public health management. JAMA 2851059-1070. - PubMed
    1. Carter, A. T., C. J. Paul, D. R. Mason, S. M. Twine, M. J. Alston, S. M. Logan, J. W. Austin, and M. W. Peck. 2009. Independent evolution of neurotoxin and flagellar genetic loci in proteolytic Clostridium botulinum. BMC Genomics 10115. - PMC - PubMed
    1. Franciosa, G., J. L. Ferreira, and C. L. Hatheway. 1994. Detection of type A, B, and E botulism neurotoxin genes in Clostridium botulinum and other Clostridium species by PCR: evidence of unexpressed type B toxin genes in type A toxigenic organisms. J. Clin. Microbiol. 321911-1917. - PMC - PubMed
    1. Hatheway, C. L. 1990. Toxigenic clostridia. Clin. Microbiol. Rev. 366-98. - PMC - PubMed
    1. Hill, K. K., T. J. Smith, C. H. Helma, L. O. Ticknor, B. T. Foley, R. T. Svensson, J. L. Brown, E. A. Johnson, L. A. Smith, R. T. Okinaka, P. J. Jackson, and J. D. Marks. 2007. Genetic diversity among botulinum neurotoxin-producing clostridial strains. J. Bacteriol. 189818-832. - PMC - PubMed

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