This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

Comment

. 2009 May;16(5):454-5; author reply 455-6.

doi: 10.1038/nsmb0509-454.

Mechanisms of APOBEC3G-catalyzed processive deamination of deoxycytidine on single-stranded DNA

Linda Chelico, Phuong Pham, Myron F Goodman

PMID: 19421154
PMCID: PMC2764237
DOI: 10.1038/nsmb0509-454

Comment

Mechanisms of APOBEC3G-catalyzed processive deamination of deoxycytidine on single-stranded DNA

Linda Chelico et al. Nat Struct Mol Biol. 2009 May.

. 2009 May;16(5):454-5; author reply 455-6.

doi: 10.1038/nsmb0509-454.

Authors

Linda Chelico, Phuong Pham, Myron F Goodman

PMID: 19421154
PMCID: PMC2764237
DOI: 10.1038/nsmb0509-454

No abstract available

PubMed Disclaimer

Comment on

Hypermutation by intersegmental transfer of APOBEC3G cytidine deaminase.
Nowarski R, Britan-Rosich E, Shiloach T, Kotler M. Nowarski R, et al. Nat Struct Mol Biol. 2008 Oct;15(10):1059-66. doi: 10.1038/nsmb.1495. Epub 2008 Sep 28. Nat Struct Mol Biol. 2008. PMID: 18820687

Similar articles

Single-stranded DNA scanning and deamination by APOBEC3G cytidine deaminase at single molecule resolution.
Senavirathne G, Jaszczur M, Auerbach PA, Upton TG, Chelico L, Goodman MF, Rueda D. Senavirathne G, et al. J Biol Chem. 2012 May 4;287(19):15826-35. doi: 10.1074/jbc.M112.342790. Epub 2012 Feb 23. J Biol Chem. 2012. PMID: 22362763 Free PMC article.
Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase.
Bransteitter R, Pham P, Scharff MD, Goodman MF. Bransteitter R, et al. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4102-7. doi: 10.1073/pnas.0730835100. Epub 2003 Mar 21. Proc Natl Acad Sci U S A. 2003. PMID: 12651944 Free PMC article.
APOBEC3G is a single-stranded DNA cytidine deaminase and functions independently of HIV reverse transcriptase.
Suspène R, Sommer P, Henry M, Ferris S, Guétard D, Pochet S, Chester A, Navaratnam N, Wain-Hobson S, Vartanian JP. Suspène R, et al. Nucleic Acids Res. 2004 Apr 30;32(8):2421-9. doi: 10.1093/nar/gkh554. Print 2004. Nucleic Acids Res. 2004. PMID: 15121899 Free PMC article.
Activation induced deaminase: the importance of being specific.
Smith HC, Bottaro A, Sowden MP, Wedekind JE. Smith HC, et al. Trends Genet. 2004 Jun;20(6):224-7. doi: 10.1016/j.tig.2004.03.012. Trends Genet. 2004. PMID: 15145573 Review.
The biochemistry of activation-induced deaminase and its physiological functions.
Larijani M, Martin A. Larijani M, et al. Semin Immunol. 2012 Aug;24(4):255-63. doi: 10.1016/j.smim.2012.05.003. Epub 2012 Jun 12. Semin Immunol. 2012. PMID: 22695318 Review.

See all similar articles

Cited by

Exploring the Role of Clustered Mutations in Carcinogenesis and Their Potential Clinical Implications in Cancer.
Li Y, Zhu R, Jin J, Guo H, Zhang J, He Z, Liang T, Guo L. Li Y, et al. Int J Mol Sci. 2024 Jun 19;25(12):6744. doi: 10.3390/ijms25126744. Int J Mol Sci. 2024. PMID: 38928450 Free PMC article. Review.
Clustered and genome-wide transient mutagenesis in human cancers: Hypermutation without permanent mutators or loss of fitness.
Roberts SA, Gordenin DA. Roberts SA, et al. Bioessays. 2014 Apr;36(4):382-393. doi: 10.1002/bies.201300140. Epub 2014 Feb 26. Bioessays. 2014. PMID: 24615916 Free PMC article.
Evaluation of anti-HIV-1 mutagenic nucleoside analogues.
Vivet-Boudou V, Isel C, El Safadi Y, Smyth RP, Laumond G, Moog C, Paillart JC, Marquet R. Vivet-Boudou V, et al. J Biol Chem. 2015 Jan 2;290(1):371-83. doi: 10.1074/jbc.M114.616383. Epub 2014 Nov 14. J Biol Chem. 2015. PMID: 25398876 Free PMC article.
Replication protein A (RPA) hampers the processive action of APOBEC3G cytosine deaminase on single-stranded DNA.
Lada AG, Waisertreiger IS, Grabow CE, Prakash A, Borgstahl GE, Rogozin IB, Pavlov YI. Lada AG, et al. PLoS One. 2011;6(9):e24848. doi: 10.1371/journal.pone.0024848. Epub 2011 Sep 15. PLoS One. 2011. PMID: 21935481 Free PMC article.
FHIT loss-induced DNA damage creates optimal APOBEC substrates: Insights into APOBEC-mediated mutagenesis.
Waters CE, Saldivar JC, Amin ZA, Schrock MS, Huebner K. Waters CE, et al. Oncotarget. 2015 Feb 20;6(5):3409-19. doi: 10.18632/oncotarget.2636. Oncotarget. 2015. PMID: 25401976 Free PMC article.

See all "Cited by" articles

References

1. Nowarski R, Britan-Rosich E, Shiloach T, Kotler M. Hypermutation by intersegmental transfer of APOBEC3G cytidine deaminase. Nat Struct Mol Biol. 2008;15:1059–1066. - PubMed
1. Berg OG, Winter RB, von Hippel PH. Diffusion-driven mechanisms of protein translocation on nucleic acids. 1. Models and theory. Biochemistry. 1981;20:6929–6948. - PubMed
1. von Hippel PH, Berg OG. Facilitated target location in biological systems. J Biol Chem. 1989;264:675–678. - PubMed
1. Stanford NP, Szczelkun MD, Marko JF, Halford SE. One- and three-dimensional pathways for proteins to reach specific DNA sites. Embo J. 2000;19:6546–6557. - PMC - PubMed
1. Pham P, Chelico L, Goodman MF. DNA deaminases AID and APOBEC3G act processively on single-stranded DNA. DNA Repair (Amst) 2007;6:689–692. - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources