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. 2009 Sep;92(3):1107-1109.
doi: 10.1016/j.fertnstert.2008.10.047. Epub 2009 May 6.

Estradiol modulation of hepatocyte growth factor by stromal fibroblasts in the female reproductive tract

Kimberly D Coleman  1 , Jacqueline A Wright  2 , Mimi Ghosh  3 , Charles R Wira  3 , John V Fahey  3
Affiliations

Estradiol modulation of hepatocyte growth factor by stromal fibroblasts in the female reproductive tract

Kimberly D Coleman et al. Fertil Steril. 2009 Sep.

Abstract

Primary human uterine, cervical, and ectocervical stromal fibroblasts constitutively secrete hepatocyte growth factor (HGF), yet only uterine stromal fibroblasts increase HGF secretion in response to estradiol. Estradiol-induced HGF secretion by uterine stromal fibroblasts may have a significant effect on uterine cancer and endometriosis.

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Figures

Figure 1
Figure 1
Treatment of uterine stromal fibroblasts with estradiol over 6 days shows that HGF secretion increases with increased exposure to estradiol (10−8 M). Conditioned media was completely removed at 48-hour intervals and replaced with fresh media with or without estradiol. The mean +/− SEM of HGF secreted in four replicates per treatment is shown. Representative of 4 donors with similar results. **p<0.01, ***p<0.001 compared to control.
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References

    1. Cooke PS, Buchanan DL, Lubahn DB, Cunha GR. Mechanism of estrogen action: lessons from the estrogen receptor-alpha knockout mouse. Biol Reprod. 1998;59:470–5. - PubMed
    1. Ito K. Hormone replacement therapy and cancers: the biological roles of estrogen and progestin in tumorigenesis are different between the endometrium and breast. Tohoku J Exp Med. 2007;212:1–12. - PubMed
    1. Rodriguez C, Patel AV, Calle EE, Jacob EJ, Thun MJ. Estrogen replacement therapy and ovarian cancer mortality in a large prospective study of US women. Jama. 2001;285:1460–5. - PubMed
    1. Smith JS, Green J, Berrington de Gonzalez A, Appleby P, Peto J, Plummer M, et al. Cervical cancer and use of hormonal contraceptives: a systematic review. Lancet. 2003;361:1159–67. - PubMed
    1. Khan KN, Masuzaki H, Fujishita A, Kitajima M, Hiraki K, Sekine I, et al. Interleukin-6- and tumour necrosis factor alpha-mediated expression of hepatocyte growth factor by stromal cells and its involvement in the growth of endometriosis. Hum Reprod. 2005;20:2715–23. - PubMed

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