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. 2009 Oct;44(10):3852-7.
doi: 10.1016/j.ejmech.2009.04.010. Epub 2009 Apr 14.

Synthesis of some novel bioactive 4-oxy/thio substituted-1H-pyrazol-5(4H)-ones via efficient cross-Claisen condensation

R Venkat Ragavan  1 , V Vijayakumar, N Suchetha Kumari
Affiliations

Synthesis of some novel bioactive 4-oxy/thio substituted-1H-pyrazol-5(4H)-ones via efficient cross-Claisen condensation

R Venkat Ragavan et al. Eur J Med Chem. 2009 Oct.

Abstract

alpha-Oxy/thio substituted-beta-keto esters were synthesized through an efficient cross-Claisen condensation of aryl oxy/thio acetic acid ethyl esters with acid chlorides, then it is converted in situ into 4-oxy/thio substituted-1H-pyrazol-5(4H)-ones by the addition of hydrazine or hydrazine derivatives and screened for their antibacterial, antifungal activities.

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