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. 2009 Nov;16(11):1059-63.
doi: 10.1016/j.phymed.2009.03.019. Epub 2009 May 7.

The antitumoral, trypanocidal and antileishmanial activities of extract and alkaloids isolated from Duguetia furfuracea

D B da Silva  1 , E C O Tulli, G C G Militão, L V Costa-Lotufo, C Pessoa, M O de Moraes, S Albuquerque, J M de Siqueira
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The antitumoral, trypanocidal and antileishmanial activities of extract and alkaloids isolated from Duguetia furfuracea

D B da Silva et al. Phytomedicine. 2009 Nov.

Abstract

The alkaloid extract and five alkaloids isolated from subterranean stem bark of Duguetia furfuracea (Annonaceae) were investigated for the following activities: antitumoral, trypanocidal and leishmanicidal. Dicentrinone showed weak cytotoxicity, but it had the strongest leishmanicidal activity (IC(50) 0.01 microM). Duguetine and duguetine beta-N-oxide caused considerable antitumoral activity in every cell lines evaluated, although duguetine was more active against trypomastigote forms (IC(50) 9.32 microM) than other alkaloids tested.

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