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Review
. 2009 Jun;30(6):296-302.
doi: 10.1016/j.tips.2009.03.003. Epub 2009 May 6.

Regulatory circuits underlying pluripotency and reprogramming

Jeong Tae Do  1 , Hans R Schöler
Affiliations
Review

Regulatory circuits underlying pluripotency and reprogramming

Jeong Tae Do et al. Trends Pharmacol Sci. 2009 Jun.

Abstract

The ability of pluripotent stem cells to differentiate into all cell types of an organism has received widespread attention in basic and clinical research and holds tremendous potential for pharmacologic and medical applications. In this review, we provide an overview of the factors and pathways involved in pluripotency and discuss a possible mechanism underlying genetic reprogramming using defined transcription factors. We specifically address the association between core transcription factors (e.g. Oct4, Sox2 and Nanog) and the cellular machinery (e.g. chromatin remodeling complex, DNA methylation, microRNA and X chromosome inactivation), which has an important role in cell fate determination.

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