The neurofibroma cell of origin: SKPs expand the playing field
- PMID: 19427284
- DOI: 10.1016/j.stem.2009.04.010
The neurofibroma cell of origin: SKPs expand the playing field
Abstract
Mounting evidence suggests that stem/progenitor cells may be the cells of origin for many tumor types. In this issue of Cell Stem Cell, Le et al. (2009) demonstrate that skin-derived precursors (SKPs) can initiate dermal neurofibromas and highlight the importance of the microenvironment in the formation of this complex tumor.
Comment on
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Cell of origin and microenvironment contribution for NF1-associated dermal neurofibromas.Cell Stem Cell. 2009 May 8;4(5):453-63. doi: 10.1016/j.stem.2009.03.017. Cell Stem Cell. 2009. PMID: 19427294 Free PMC article.
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