Using small molecules to great effect in stem cell differentiation
- PMID: 19427285
- DOI: 10.1016/j.stem.2009.04.012
Using small molecules to great effect in stem cell differentiation
Abstract
Several recent reports, including two Cell Stem Cell papers (Zhu et al., 2009 [this issue]; Borowiak et al., 2009), screened small molecule libraries for compounds that promote embryonic stem cell differentiation. Their combined success helps bypass challenges associated with using natural protein factors and has revealed insights into controlling stem cell differentiation.
Comment on
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Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells.Cell Stem Cell. 2009 Apr 3;4(4):348-58. doi: 10.1016/j.stem.2009.01.014. Cell Stem Cell. 2009. PMID: 19341624 Free PMC article.
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A small molecule primes embryonic stem cells for differentiation.Cell Stem Cell. 2009 May 8;4(5):416-26. doi: 10.1016/j.stem.2009.04.001. Cell Stem Cell. 2009. PMID: 19427291
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