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. 2009 Jul-Sep;8(3):324-30.
doi: 10.1016/j.brachy.2008.12.008. Epub 2009 May 9.

Photon activation therapy and brachytherapy

Brenda H Laster  1 , Dabney W Dixon, Sara Novick, Jon P Feldman, Veronique Seror, Zvi I Goldbart, John A Kalef-Ezra
Affiliations

Photon activation therapy and brachytherapy

Brenda H Laster et al. Brachytherapy. 2009 Jul-Sep.

Abstract

Purpose: In photon activation therapy (PAT), energy deposition at critical sites within a tumor can be increased by complexing the DNA with higher Z atoms, and provoking the emission of Auger electrons after inducing a photoelectric effect. This in vivo study evaluates the hypothesis using X-rays from palladium-103 seeds to excite the L-edge of platinum (Pt) atoms bound to the DNA of cancerous cells.

Methods and materials: Pt (II) tetrakis(N-methyl-4-pyridyl) porphyrin chloride was used to locate Pt atoms adjacent to the DNA of the KHJJ murine mammary carcinoma; a 2.3-mCi palladium-103 seed was implanted in the tumor.

Results: The tumor periphery received subtherapeutic doses. The rate of tumor growth in mice treated with PAT was slower than in mice treated with brachytherapy only.

Conclusions: The tumor growth delay for PAT-treated mice is attributed to Auger emission from Pt atoms that produced substantial local damage. However, other co-existing mechanisms cannot be ruled out.

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