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. 2009 Apr 27;123(2):132-7.
doi: 10.1016/j.imlet.2009.03.001. Epub 2009 Mar 18.

An exopolysaccharide produced by Geobacillus thermodenitrificans strain B3-72: antiviral activity on immunocompetent cells

Adriana Arena  1 , Concetta Gugliandolo, Giovanna Stassi, Bernadette Pavone, Daniela Iannello, Giuseppe Bisignano, Teresa Luciana Maugeri
Affiliations

An exopolysaccharide produced by Geobacillus thermodenitrificans strain B3-72: antiviral activity on immunocompetent cells

Adriana Arena et al. Immunol Lett. .

Abstract

The immunomodulatory and antiviral effects of an extracellular polysaccharide (EPS-2), produced by a strain of Geobacillus thermodenitrificans isolated from a shallow marine vent of Vulcano Island (Italy), were evaluated. In the present study, we show for the first time that EPS-2 treatment hinder HSV-2 replication in human peripheral blood mononuclear cells (PBMC) but not in WISH cells. In fact, high levels of IFN-alpha, IL-12, IFN-gamma, TNF-alpha, IL-18 were detected in supernatants of EPS-2 treated PBMC. Moreover, this effect was dose-dependent. Taken together, our results confirm that the immunological disorders determined by HSV-2 could be partially restored by treatment with EPS-2.

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