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Review
. 2009 May;41(5):352-61.
doi: 10.1093/abbs/gmp029.

Molecular properties, functions, and potential applications of NAD kinases

Feng Shi  1 , Yongfu Li, Ye Li, Xiaoyuan Wang
Affiliations
Free article
Review

Molecular properties, functions, and potential applications of NAD kinases

Feng Shi et al. Acta Biochim Biophys Sin (Shanghai). 2009 May.
Free article

Abstract

NAD kinase catalyzes the phosphorylation of NAD(H) to form NADP(H), using ATP as phosphoryl donor. It is the only key enzyme leading to the de novo NADP(+)/NADPH biosynthesis. Coenzymes such as NAD(H) and NADP(H) are known for their important functions. Recent studies have partially demonstrated that NAD kinase plays a crucial role in the regulation of NAD(H)/NADP(H) conversion. Here, the molecular properties, physiologic functions, and potential applications of NAD kinase are discussed.

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