Estimating the number of channels in patch recordings
- PMID: 19431799
- PMCID: PMC1260080
- DOI: 10.1016/S0006-3495(91)82069-0
Estimating the number of channels in patch recordings
Abstract
The estimation of the number of channels in a patch was assumed to be equivalent to the estimation of the binomial parameter n. Seven estimators were evaluated, using data sets simulated for a range of parameters appropriate for single channel recording experiments. No single estimator was best for all parameters; a combination of estimators is a possible option to avoid the biases of individual estimators. All estimators were highly accurate in estimating n in the case that n = 1. For n </= 4 the simplest estimator, the maximum number of simultaneously open channels, was the best, For larger values of n the best estimators were Bayesian.
Similar articles
-
Estimators of the local false discovery rate designed for small numbers of tests.Stat Appl Genet Mol Biol. 2012 Oct 12;11(5):4. doi: 10.1515/1544-6115.1807. Stat Appl Genet Mol Biol. 2012. PMID: 23079518
-
Reliability of maximum number of simultaneously open channels as an estimator for the number of channels in single-channel recordings.J Theor Biol. 1995 Mar 7;173(1):61-5. doi: 10.1006/jtbi.1995.0043. J Theor Biol. 1995. PMID: 7537835
-
Bayesian procedures for the estimation of mutation rates from fluctuation experiments.Genetics. 1996 Jan;142(1):313-26. doi: 10.1093/genetics/142.1.313. Genetics. 1996. PMID: 8770608 Free PMC article.
-
Minimax Estimation of Functionals of Discrete Distributions.IEEE Trans Inf Theory. 2015 May;61(5):2835-2885. doi: 10.1109/tit.2015.2412945. Epub 2015 Mar 13. IEEE Trans Inf Theory. 2015. PMID: 29375152 Free PMC article.
-
A comparison of heterogeneity variance estimators in combining results of studies.Stat Med. 2007 Apr 30;26(9):1964-81. doi: 10.1002/sim.2688. Stat Med. 2007. PMID: 16955539
Cited by
-
Evidence for non-independent gating of P2X2 receptors expressed in Xenopus oocytes.BMC Neurosci. 2002 Nov 6;3:17. doi: 10.1186/1471-2202-3-17. BMC Neurosci. 2002. PMID: 12421468 Free PMC article.
-
Different effects on gating of three myotonia-causing mutations in the inactivation gate of the human muscle sodium channel.J Physiol. 1995 Aug 15;487(1):107-14. doi: 10.1113/jphysiol.1995.sp020864. J Physiol. 1995. PMID: 7473241 Free PMC article.
-
Dual activity of aminoarylthiazoles on the trafficking and gating defects of the cystic fibrosis transmembrane conductance regulator chloride channel caused by cystic fibrosis mutations.J Biol Chem. 2011 Apr 29;286(17):15215-26. doi: 10.1074/jbc.M110.184267. Epub 2011 Mar 7. J Biol Chem. 2011. PMID: 21383017 Free PMC article.
-
Mechanosensitivity of Nav1.5, a voltage-sensitive sodium channel.J Physiol. 2010 Dec 15;588(Pt 24):4969-85. doi: 10.1113/jphysiol.2010.199034. Epub 2010 Nov 1. J Physiol. 2010. PMID: 21041530 Free PMC article.
-
Description of interacting channel gating using a stochastic Markovian model.Bull Math Biol. 1996 Jan;58(1):141-74. doi: 10.1007/BF02458286. Bull Math Biol. 1996. PMID: 8819758
References
LinkOut - more resources
Full Text Sources