Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Jun 18;583(12):1817-24.
doi: 10.1016/j.febslet.2009.05.007. Epub 2009 May 9.

IQGAPs in cancer: a family of scaffold proteins underlying tumorigenesis

Colin D White  1 , Matthew D Brown, David B Sacks
Affiliations
Review

IQGAPs in cancer: a family of scaffold proteins underlying tumorigenesis

Colin D White et al. FEBS Lett. .

Abstract

The IQGAP family comprises three proteins in humans. The best characterized is IQGAP1, which participates in protein-protein interactions and integrates diverse signaling pathways. IQGAP2 and IQGAP3 harbor all the domains identified in IQGAP1, but their biological roles are poorly defined. Proteins that bind IQGAP1 include Cdc42 and Rac1, E-cadherin, beta-catenin, calmodulin and components of the mitogen-activated protein kinase pathway, all of which are involved in cancer. Here, we summarize the biological functions of IQGAPs that may contribute to neoplasia. Additionally, we review published data which implicate IQGAPs in cancer and tumorigenesis. The cumulative evidence suggests IQGAP1 is an oncogene while IQGAP2 may be a tumor suppressor.

PubMed Disclaimer

Figures

Figure 1
Figure 1
A schematic diagram of human IQGAP proteins. Domain structure (adapted from SMART and Pfam databases) and percentage amino acid identity of human IQGAP1, IQGAP2 and IQGAP3 are shown. Note the presence of four IQ motifs in IQGAP2 [3]. CHD, calponin homology domain; WW, poly-proline protein-protein domain; IQ, IQ domain (with four IQ motifs); GRD, RasGAP-related domain; RasGAP_C, carboxy-terminal sequence found in members of the IQGAP family.
See this image and copyright information in PMC

References

    1. Briggs MW, Sacks DB. IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton. FEBS Lett. 2003;542:7–11. - PubMed
    1. Weissbach L, Settleman J, Kalady MF, Snijders AJ, Murthy AE, Yan YX, Bernards A. Identification of a human RasGAP-related protein containing calmodulin-binding motifs. J Biol Chem. 1994;269:20517–21. - PubMed
    1. Brill S, Li S, Lyman CW, Church DM, Wasmuth JJ, Weissbach L, Bernards A, Snijders AJ. The Ras GTPase-activating protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases. Mol Cell Biol. 1996;16:4869–78. - PMC - PubMed
    1. Wang S, et al. IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth. J Cell Sci. 2007;120:567–77. - PubMed
    1. Briggs MW, Sacks DB. IQGAP proteins are integral components of cytoskeletal regulation. EMBO Rep. 2003;4:571–574. - PMC - PubMed

Publication types

MeSH terms