Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Jun;10(6):371-80.
doi: 10.1038/nrg2578.

Towards better mouse models: enhanced genotypes, systemic phenotyping and envirotype modelling

Johannes Beckers  1 , Wolfgang Wurst, Martin Hrabé de Angelis
Affiliations
Review

Towards better mouse models: enhanced genotypes, systemic phenotyping and envirotype modelling

Johannes Beckers et al. Nat Rev Genet. 2009 Jun.

Abstract

The mouse is the leading mammalian model organism for basic genetic research and for studying human diseases. Coordinated international projects are currently in progress to generate a comprehensive map of mouse gene functions - the first for any mammalian genome. There are still many challenges ahead to maximize the value of the mouse as a model, particularly for human disease. These involve generating mice that are better models of human diseases at the genotypic level, systemic (assessing all organ systems) and systematic (analysing all mouse lines) phenotyping of existing and new mouse mutant resources, and assessing the effects of the environment on phenotypes.

PubMed Disclaimer

References

    1. Nature. 2002 Nov 14;420(6912):145-50 - PubMed
    1. Mamm Genome. 2008 Oct-Dec;19(10-12):703-12 - PubMed
    1. Cell. 2008 Nov 28;135(5):852-64 - PubMed
    1. Nat Med. 2005 Apr;11(4):423-8 - PubMed
    1. Mamm Genome. 2008 Jun;19(6):382-9 - PubMed

Publication types

LinkOut - more resources