Hyaluronan, platelets, and monocytes: a novel pro-inflammatory triad

Affiliations

Review

Gustavo B Menezes et al. Am J Pathol. 2009 Jun.

. 2009 Jun;174(6):1993-5.

doi: 10.2353/ajpath.2009.081138. Epub 2009 May 12.

¹ Immunology Research Group, Department of Physiologyand Biophysics, Institute of Infection, Immunity andInflammation, University of Calgary, Alberta, Canada.

Abstract

This commentary reports on the role of platelets and hyaluronan in activating monocytes.

Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines.
de la Motte C, Nigro J, Vasanji A, Rho H, Kessler S, Bandyopadhyay S, Danese S, Fiocchi C, Stern R. de la Motte C, et al. Am J Pathol. 2009 Jun;174(6):2254-64. doi: 10.2353/ajpath.2009.080831. Epub 2009 May 14. Am J Pathol. 2009. PMID: 19443707 Free PMC article.

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