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. 2009 Feb;5(1):139-49.
doi: 10.2147/tcrm.s3068. Epub 2009 Mar 26.

Mycophenolate mofetil: safety and efficacy in the prophylaxis of acute kidney transplantation rejection

Pranav Dalal  1 , Monica Grafals, Darshika Chhabra, Lorenzo Gallon
Affiliations

Mycophenolate mofetil: safety and efficacy in the prophylaxis of acute kidney transplantation rejection

Pranav Dalal et al. Ther Clin Risk Manag. 2009 Feb.

Abstract

Mycophenolate mofetil (MMF), a prodrug of mycophenolic acid (MPA), is an inhibitor of inosine monophosphate dehydrogenase (IMPDH). It preferentially inhibits denovo pathway of guanosine nucleotide synthesis in T and B-lymphocytes and prevents their proliferation, thereby suppresses both cell mediated and humoral immune responses. Clinical trials in kidney transplant recipients have shown the efficacy of MMF in reducing the incidence and severity of acute rejection episodes. It also improves long term graft function as well as graft and patient survival in kidney transplant recipients. MMF is useful as a component of toxicity sparing regimens to reduce or avoid exposure of steroids or calcineurin inhibitor (CNI). Enteric-coated mycophenolate sodium (EC-MPS) can be used as an alternative immunosuppressive agent in kidney transplant recipients with efficacy and safety profile similar to MMF.

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Figures

Figure 1
Figure 1
Chemical structure of mycophenolate mofetil (MMF) – the morpholinoethyl ester of mycophenolic acid (MPA) – mycophenolate.
Figure 2
Figure 2
Mechanism of action – Inhibition of de novo pathway of purine synthesis by mycophenolate mofetil. Abbreviations: HGPRT, hypoxanthine-guanine phosphoribosyl; IMPDH, inosine monophosphate dehydrogenase.
See this image and copyright information in PMC

References

    1. Eugui EM, Almquist SJ, Muller CD, Allison AC. Lymphocyte-selective cytostatic and immunosuppressive effects of mycophenolic acid in vitro: role of deoxyguanosine nucleotide depletion. Scand J Immunol. 1991;33(2):161–173. - PubMed
    1. Gosio B. Sperimentate su culture pure di bacilli del carbpnchio demostrarano notevole potere antisettica. G Accad Med Torino. 1983;61:484.
    1. Franklin TJ, Cook JM. The inhibition of nucleic acid synthesis by mycophenolic acid. Biochem J. 1969;113(3):515–524. - PMC - PubMed
    1. Morris RE, Wang J, Blum JR, et al. Immunosuppressive effects of the morpholinoethyl ester of mycophenolic acid (RS-61443) in rat and nonhuman primate recipients of heart allografts. Transplant Proc. 1991 Apr;23(2 Suppl 2):19–25. - PubMed
    1. Platz KP, Bechstein WO, Eckhoff DE, Suzuki Y, Sollinger HW.RS-61443 reverses acute allograft rejection in dogs Surgery 19911104736–740.discussion 40–41. - PubMed