Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2009;36(1):55-7.

First report of tirofiban-induced anemia (found in combination with severe thrombocytopenia)

Dimitris Sakellariou  1 , Socrates Pastromas, Spyridon Koulouris, Antonis S Manolis
Affiliations
Case Reports

First report of tirofiban-induced anemia (found in combination with severe thrombocytopenia)

Dimitris Sakellariou et al. Tex Heart Inst J. 2009.

Abstract

We describe the case of a 58-year-old man who developed acute severe anemia and thrombocytopenia after the administration of tirofiban following coronary artery angioplasty. The intravenous administration of IgG immunoglobulin completely resolved both the anemia and the thrombocytopenia. Although thrombocytopenia has been reported as a sequela to the use of tirofiban, there has been no prior report of a link between tirofiban use and anemia. Our successful resolution of both the anemia and the thrombocytopenia with immunoglobulin supports the theory that these severe sequelae of tirofiban are of autoimmune origin.

Keywords: Anemia; platelet aggregation inhibitors; platelet glycoprotein GPIIb/IIIa complex/drug effects; thrombocytopenia; tirofiban.

PubMed Disclaimer

Figures

None
Fig. 1 Time-course of platelet count and hematocrit changes after tirofiban intake.
See this image and copyright information in PMC

References

    1. Karvouni E, Katritsis DG, Ioannidis JP. Intravenous glycoprotein IIb/IIIa receptor antagonists reduce mortality after percutaneous coronary interventions. J Am Coll Cardiol 2003; 41(1):26–32. - PubMed
    1. Abrams CS, Cines DB. Thrombocytopenia after treatment with platelet glycoprotein IIb/IIIa inhibitors. Curr Hematol Rep 2004;3(2):143–7. - PubMed
    1. Dasgupta H, Blankenship JC, Wood GC, Frey CM, Demko SL, Menapace FJ. Thrombocytopenia complicating treatment with intravenous glycoprotein IIb/IIIa receptor inhibitors: a pooled analysis. Am Heart J 2000;140(2):206–11. - PubMed
    1. Merlini PA, Rossi M, Menozzi A, Buratti S, Brennan DM, Moliterno DJ, et al. Thrombocytopenia caused by abciximab or tirofiban and its association with clinical outcome in patients undergoing coronary stenting. Circulation 2004;109 (18):2203–6. - PubMed
    1. Tcheng JE. Clinical challenges of platelet glycoprotein IIb/IIIa receptor inhibitor therapy: bleeding, reversal, thrombocytopenia, and retreatment. Am Heart J 2000;139(2 Pt 2):S38-45. - PubMed

Publication types

MeSH terms