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Case Reports
. 2009 May-Jun;221(3):174-5.
doi: 10.1055/s-0029-1220702. Epub 2009 May 12.

Lepirudin treatment in a girl with iliac vein thrombosis, severe pulmonary embolism and suspected heparin-induced thrombocytopenia (HIT) II

K N Walter  1 , M Erlacher, M Uhl, U Budde, G Nowak, A Superti-Furga, B Zieger
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Case Reports

Lepirudin treatment in a girl with iliac vein thrombosis, severe pulmonary embolism and suspected heparin-induced thrombocytopenia (HIT) II

K N Walter et al. Klin Padiatr. 2009 May-Jun.

Abstract

We report on a 15-year-old girl referred to us for dyspnea. Investigations revealed multiple pulmonary emboli originating from iliac vein thrombosis. As under heparin therapy, d-dimers rose again and the thrombus grew significantly in size while platelet count decreased by >30%. A diagnosis of heparin-induced thrombocytopenia (HIT) type II was suspected, heparin-treatment was stopped and lepirudin therapy was started successfully at a doses of 0.15 mg/kg bw/hr.

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