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Comment
. 2009;13(2):138.
doi: 10.1186/cc7789. Epub 2009 Apr 29.

'Relation, association, attribution ...' - the multiple faces of death in critical care medicine

Susanne Toussaint  1 , Herwig Gerlach
Affiliations
Comment

'Relation, association, attribution ...' - the multiple faces of death in critical care medicine

Susanne Toussaint et al. Crit Care. 2009.

Abstract

Mortality is one of the most important quality markers in critical care, and there have been many epidemiological studies trying to identify risk factors to better understand the mechanisms leading to death in this complex disease. One of the major problems is that there are multiple factors contributing to fatal outcome of septic patients, and it is difficult to distinguish between those that are independent from the acute disease (comorbidities and 'risk factors') and those that are directly involved in the pathomechanisms of sepsis, thus leading to the 'sepsis-attributable' mortality. In this short commentary, some examples of different approaches of how to analyze data on mortality are presented.

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References

    1. Melamed A, Sorvillo FJ. The burden of sepsis-associated mortality in the United States from 1999 to 2005: an analysis of multiple-cause-of-death data. Crit Care. 2009;13:R28. doi: 10.1186/cc7733. - DOI - PMC - PubMed
    1. Dombrovskiy VY, Martin AA, Sunderram J, Paz HL. Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003. Crit Care Med. 2007;35:1244–1250. doi: 10.1097/01.CCM.0000261890.41311.E9. - DOI - PubMed
    1. Christaki E, Opal SM. Is the mortality rate for septic shock really decreasing? Curr Opin Crit Care. 2008;14:580–586. doi: 10.1097/MCC.0b013e32830f1e25. - DOI - PubMed
    1. Bercault N, Boulain T, Kuteifan K, Wolf M, Runge I, Fleury JC. Obesity-related excess mortality rate in an adult intensive are unit: a risk-adjusted matched cohort study. Crit Care Med. 2004;32:998–1003. doi: 10.1097/01.CCM.0000119422.93413.08. - DOI - PubMed
    1. Classen DC, Pestotnik SL, Evans RS, Lloyd JF, Burke JP. Adverse drug events in hospitalized patients: excess length of stay, extra costs, and attributable mortality. JAMA. 1997;277:301–306. doi: 10.1001/jama.277.4.301. - DOI - PubMed