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Multicenter Study
. 2009 Sep;58(9):1222-8.
doi: 10.1016/j.metabol.2009.04.007. Epub 2009 Jun 18.

Ala54Thr polymorphism of the fatty acid binding protein 2 gene and saturated fat intake in relation to lipid levels and insulin resistance: the Coronary Artery Risk Development in Young Adults (CARDIA) study

Alanna M Chamberlain  1 , Pamela J Schreiner, Myriam Fornage, Catherine M Loria, David Siscovick, Eric Boerwinkle
Affiliations
Multicenter Study

Ala54Thr polymorphism of the fatty acid binding protein 2 gene and saturated fat intake in relation to lipid levels and insulin resistance: the Coronary Artery Risk Development in Young Adults (CARDIA) study

Alanna M Chamberlain et al. Metabolism. 2009 Sep.

Abstract

The Thr54 allele of the intestinal fatty acid-binding protein Ala54Thr functional polymorphism (FABP2) is associated with increased fat oxidation and insulin resistance. We determined the cross-sectional associations of the FABP2 gene with lipid levels and insulin resistance in 2148 participants who completed the year-20 examination of the Coronary Artery Risk Development in Young Adults (CARDIA) study. No significant difference in total cholesterol, low-density or high-density lipoprotein cholesterol, triglycerides, high-density lipoprotein cholesterol to total cholesterol ratio, or homeostasis model assessment of insulin resistance (HOMA-IR) was found between FABP2 genotypes. However, in the presence of a high-saturated fat diet (>/=53.2 g/d, the 90th percentile for the population), the AA/AG genotypes (carriers of the Thr54 allele) of FABP2 had statistically significantly higher levels of log(HOMA-IR) (P = .006) and a lower high-density lipoprotein cholesterol to total cholesterol ratio (P = .03), and borderline statistically significantly higher levels of total cholesterol, low-density lipoprotein cholesterol, and log(triglycerides) (P values = .08, .07, and .05, respectively) compared with those with the GG genotype (Ala54 homozygotes). Lipid levels and log(HOMA-IR) did not vary by genotype with saturated fat intake less than 53.2 g/d. Limiting dietary saturated fat intake may be particularly important among carriers of the A allele of FABP2.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1. Multivariable-Adjusted* Plots of Association between Genotype and Endpoints Stratified on the 90th Percentile of Saturated Fat Intake, The CARDIA Study, 2005–2006
*Models are adjusted for race, sex, center, educational attainment, and the following at year 20: age, waist circumference, alcohol intake, smoking status, and daily total caloric intake. SF refers to daily saturated fat intake. N=2148 for the lipid models. Among those with saturated fat intake above the 90th percentile, 98 were AA/AG and 121 were GG for FABP2. Among those with low/normal saturated fat intake, 813 were AA/AG and 1116 were GG. N=2145 for the HOMA-IR model. Among those with saturated fat intake above the 90th percentile, 97 were AA/AG and 121 were GG for FABP2. Among those with low/normal saturated fat intake, 813 were AA/AG and 1114 were GG.
Figure 1
Figure 1. Multivariable-Adjusted* Plots of Association between Genotype and Endpoints Stratified on the 90th Percentile of Saturated Fat Intake, The CARDIA Study, 2005–2006
*Models are adjusted for race, sex, center, educational attainment, and the following at year 20: age, waist circumference, alcohol intake, smoking status, and daily total caloric intake. SF refers to daily saturated fat intake. N=2148 for the lipid models. Among those with saturated fat intake above the 90th percentile, 98 were AA/AG and 121 were GG for FABP2. Among those with low/normal saturated fat intake, 813 were AA/AG and 1116 were GG. N=2145 for the HOMA-IR model. Among those with saturated fat intake above the 90th percentile, 97 were AA/AG and 121 were GG for FABP2. Among those with low/normal saturated fat intake, 813 were AA/AG and 1114 were GG.
Figure 1
Figure 1. Multivariable-Adjusted* Plots of Association between Genotype and Endpoints Stratified on the 90th Percentile of Saturated Fat Intake, The CARDIA Study, 2005–2006
*Models are adjusted for race, sex, center, educational attainment, and the following at year 20: age, waist circumference, alcohol intake, smoking status, and daily total caloric intake. SF refers to daily saturated fat intake. N=2148 for the lipid models. Among those with saturated fat intake above the 90th percentile, 98 were AA/AG and 121 were GG for FABP2. Among those with low/normal saturated fat intake, 813 were AA/AG and 1116 were GG. N=2145 for the HOMA-IR model. Among those with saturated fat intake above the 90th percentile, 97 were AA/AG and 121 were GG for FABP2. Among those with low/normal saturated fat intake, 813 were AA/AG and 1114 were GG.
Figure 1
Figure 1. Multivariable-Adjusted* Plots of Association between Genotype and Endpoints Stratified on the 90th Percentile of Saturated Fat Intake, The CARDIA Study, 2005–2006
*Models are adjusted for race, sex, center, educational attainment, and the following at year 20: age, waist circumference, alcohol intake, smoking status, and daily total caloric intake. SF refers to daily saturated fat intake. N=2148 for the lipid models. Among those with saturated fat intake above the 90th percentile, 98 were AA/AG and 121 were GG for FABP2. Among those with low/normal saturated fat intake, 813 were AA/AG and 1116 were GG. N=2145 for the HOMA-IR model. Among those with saturated fat intake above the 90th percentile, 97 were AA/AG and 121 were GG for FABP2. Among those with low/normal saturated fat intake, 813 were AA/AG and 1114 were GG.
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References

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