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. 2009 Jul;47(7):2292-4.
doi: 10.1128/JCM.02439-08. Epub 2009 May 13.

Genotypic prediction of human immunodeficiency virus type 1 CRF02-AG tropism

Stéphanie Raymond  1 , Pierre Delobel, Maud Mavigner, Michelle Cazabat, Corinne Souyris, Stéphanie Encinas, Karine Sandres-Sauné, Christophe Pasquier, Bruno Marchou, Patrice Massip, Jacques Izopet
Affiliations

Genotypic prediction of human immunodeficiency virus type 1 CRF02-AG tropism

Stéphanie Raymond et al. J Clin Microbiol. 2009 Jul.

Abstract

We assessed the performance of genotypic algorithms for predicting the tropism of human immunodeficiency virus type 1 coreceptor usage in 52 patients infected with the CRF02-AG subtype. The combined criteria of the 11/25 and net charge rules accurately detected CXCR4-using CRF02-AG viruses, whereas the Geno2pheno tool lacked sensitivity and the position-specific scoring matrix (PSSM) tool WebPSSM lacked specificity.

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