Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2009;28(3):243-55.
doi: 10.1080/10641950801986720.

A comparison of prediction equations for estimating glomerular filtration rate in pregnancy

Sofia B Ahmed  1 , Rhonda Bentley-Lewis, Norman K Hollenberg, Steven W Graves, Ellen W Seely
Affiliations
Comparative Study

A comparison of prediction equations for estimating glomerular filtration rate in pregnancy

Sofia B Ahmed et al. Hypertens Pregnancy. 2009.

Abstract

Objective: To compare existing glomerular filtration rate (GFR) prediction equations with the gold standard, inulin clearance, in pregnancy.

Methods: Five equations were assessed for precision, bias, and accuracy in prediction of true GFR, measured by inulin clearance in 12 healthy, pregnant women during the second (T2) and third (T3) trimesters and in postpartum (PP).

Results: Precision was greatest with 24-hour creatinine clearance estimation of GFR (R(2) = 13% (T2), R(2) = 26% (T3)). Other than 100/SCr, all equations underestimated true GFR. 30% accuracy was greatest in 100/SCr (83% (T2), 92% (T3)).

Conclusions: Current GFR prediction formulae do not appear to be sufficient for estimating GFR in the gravid state.

PubMed Disclaimer

Conflict of interest statement

CONFLICT OF INTEREST STATEMENT

The results presented in this paper have not been published previously in whole or part, except in abstract format at the 2006 International Society for the Study of Hypertension in Pregnancy World Congress in Lisbon, Portugal and there are no potential conflicts of interest.

Figures

Figure 1
Figure 1
Comparison of equations to predict GFR. The values of R2 indicate the percentage of variance of GFR accounted for by the equation. Abbreviations: T2, 2nd trimester; T3, 3rd trimester; PP, Postpartum.
See this image and copyright information in PMC

References

    1. Lindheimer MD, Davison JM, Katz AI. The kidney and hypertension in pregnancy: Twenty exciting years. Semin Nephrol. 2001;21:173–189. - PubMed
    1. Jones DC, Hayslett JP. Outcome of pregnancy in women with moderate or severe renal insufficiency. N Engl J Med. 1996;335:226–232. - PubMed
    1. Lin J, Knight EL, Hogan ML, Singh AK. A comparison of prediction equations for estimating glomerular filtration rate in adults without kidney disease. J Am Soc Nephrol. 2003;14:2573–2580. - PubMed
    1. Rule AD, Larson TS, Bergstralh EJ, Slezak JM, Jacobsen SJ, Cosio FG. Using serum creatinine to estimate glomerular filtration rate: Accuracy in good health and in chronic kidney disease. Ann Intern Med. 2004;141:929–937. - PubMed
    1. Poggio ED, Wang X, Greene T, Van Lente F, Hall PM. Performance of the modification of diet in renal disease and cockcroft-gault equations in the estimation of gfr in health and in chronic kidney disease. J Am Soc Nephrol. 2005;16:459–466. - PubMed

Publication types

LinkOut - more resources