Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Jun 15;19(12):3328-32.
doi: 10.1016/j.bmcl.2009.04.044. Epub 2009 Apr 18.

The discovery of novel calcium sensing receptor negative allosteric modulators

Gayatri Balan  1 , Jonathan Bauman, Samit Bhattacharya, Mayda Castrodad, David R Healy, Michael Herr, Paul Humphries, Sandra Jennings, Amit S Kalgutkar, Brendon Kapinos, Vishal Khot, Kimberly Lazarra, Mei Li, Yan Li, Constantin Neagu, Robert Oliver, David W Piotrowski, David Price, Hong Qi, Holly A Simmons, James Southers, Liuqing Wei, Yan Zhang, Vishwas M Paralkar
Affiliations

The discovery of novel calcium sensing receptor negative allosteric modulators

Gayatri Balan et al. Bioorg Med Chem Lett. .

Abstract

The design and profile of a series of zwitterionic calcium sensing receptor negative allosteric modulators is described. Evaluation of key analogues using a rat model demonstrate a robust response, significantly improved potency over ronacaleret and have the potential as an oral, anabolic treatment for osteoporosis.

PubMed Disclaimer

MeSH terms

LinkOut - more resources