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Multicenter Study
. 2009 Jun 19;23(10):1227-34.
doi: 10.1097/QAD.0b013e32832bd7af.

HIV infection and the risk of diabetes mellitus

Adeel A Butt  1 , Kathleen McGinnis, Maria C Rodriguez-Barradas, Stephen Crystal, Michael Simberkoff, Matthew Bidwell Goetz, David Leaf, Amy C Justice; Veterans Aging Cohort Study
Affiliations
Multicenter Study

HIV infection and the risk of diabetes mellitus

Adeel A Butt et al. AIDS. .

Abstract

Background: The influence of HIV infection on the risk of diabetes is unclear. We determined the association and predictors of prevalent diabetes mellitus in HIV infected and uninfected veterans.

Methods: We determined baseline prevalence and risk factors for diabetes between HIV infected and uninfected veterans in the Veterans Aging Cohort Study. Logistic regression was used to determine the odds of diabetes in HIV infected and uninfected persons.

Results: We studied 3227 HIV-infected and 3240 HIV-uninfected individuals. HIV-infected individuals were younger, more likely to be black males, have HCV coinfection and a lower BMI. HIV-infected individuals had a lower prevalence of diabetes at baseline (14.9 vs. 21.4%, P < 0.0001). After adjustment for known risk factors, HIV-infected individuals had a lower risk of diabetes (odds ratio = 0.84, 95% confidence interval = 0.72-0.97). Increasing age, male sex, minority race, and BMI were associated with an increased risk. The odds ratio for diabetes associated with increasing age, minority race and BMI were greater among HIV-infected veterans. HCV coinfection and nucleoside and nonnucleoside reverse transcriptase inhibitor therapy were associated with a higher risk of diabetes in HIV-infected veterans.

Conclusion: Although HIV infection itself is not associated with increased risk of diabetes, increasing age; HCV coinfection and BMI have a more profound effect upon the risk of diabetes among HIV-infected persons. Further, long-term ARV treatment also increases risk. Future studies will need to determine whether incidence of diabetes mellitus differs by HIV status.

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Conflict of interest statement

Conflict of Interest: The authors report no conflict of interest.

References

    1. Goulet JL, Fultz SL, McGinnis KA, Justice AC. Relative prevalence of comorbidities and treatment contraindications in HIV-mono-infected and HIV/HCV-co-infected veterans. AIDS. 2005;19(Suppl 3):S99–S105. - PubMed
    1. Goulet JL, Fultz SL, Rimland D, et al. Aging and infectious diseases: do patterns of comorbidity vary by HIV status, age, and HIV severity? Clin Infect Dis. 2007;45(12):1593–1601. - PMC - PubMed
    1. Kilbourne AM, Justice AC, Rabeneck L, Rodriguez-Barradas M, Weissman S. General medical and psychiatric comorbidity among HIV-infected veterans in the post-HAART era. J Clin Epidemiol. 2001;54(Suppl 1):S22–S28. - PubMed
    1. Butt AA, Fultz SL, Kwoh CK, Kelley D, Skanderson M, Justice AC. The Risk of Diabetes in HIV Infected Veterans in the Pre- and Post-HAART Era and the Role of Hepatitis C Virus Co-infection. Hepatology. 2004;40:115–119. - PubMed
    1. Brown TT, Cole SR, Li X, et al. Antiretroviral therapy and the prevalence and incidence of diabetes mellitus in the multicenter AIDS cohort study. Arch Intern Med. 2005;165(10):1179–1184. - PubMed

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