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Comment
. 2009 Jun;75(11):1137-1139.
doi: 10.1038/ki.2009.55.

Ablation of klotho and premature aging: is 1,25-dihydroxyvitamin D the key middleman?

Yuen Fei Wong  1 , Qihe Xu  2
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Comment

Ablation of klotho and premature aging: is 1,25-dihydroxyvitamin D the key middleman?

Yuen Fei Wong et al. Kidney Int. 2009 Jun.
Free article

Abstract

The reversal of soft-tissue abnormalities and prolonged lifespan observed in klotho(-/-) mice following genetic inactivation of 1alpha-hydroxylase underscores the pathophysiological role of 1,25-dihydroxyvitamin D in mediating some of the premature aging-like features observed in klotho(-/-) mice.

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