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. 2008 Jul 31:2008:2408.

Opioids in people with cancer-related pain

Columba Quigley  1
Affiliations

Opioids in people with cancer-related pain

Columba Quigley. BMJ Clin Evid. .

Abstract

Introduction: Up to 80% of people with cancer experience pain at some time during their illness, and most will need opioid analgesics. This review assesses how different opioid analgesics compare, in terms of both pain control and adverse effects, in people with cancer.

Methods and outcomes: We conducted a systematic review and aimed to answer the following clinical question: what are the effects of opioids in treating cancer-related pain? We searched: Medline, Embase, The Cochrane Library, and other important databases up to July 2007 (BMJ Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).

Results: We found 22 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.

Conclusions: In this systematic review, we present information relating to the effectiveness and safety of the following interventions: codeine, dihydrocodeine, transdermal fentanyl, hydromorphone, methadone, morphine, oxycodone, and tramadol.

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References

    1. McGuire DB. Occurrence of cancer pain. J Natl Cancer Inst Monogr 2004;32:51–55. - PubMed
    1. World Health Organization. WHO definition of palliative care. http://www.who.int/cancer/palliative/definition/en/ (last accessed 30 June 2008).
    1. National Institute for Clinical Excellence. Definitions of supportive and palliative care. In: Improving Supportive and Palliative Care for Adults with Cancer. National Institute for Clinical Excellence. March 2004. Introduction C, 17–22.
    1. Klepstad P, Kaasa S, Cherny N, et al. Research Steering Committee of the EAPC. Pain and pain treatments in European palliative care units. A cross sectional survey from the European Association for Palliative Care Research Network. Palliat Med 2005;19:477–484. - PubMed
    1. Wiffen PJ, Edwards JE, Barden J, et al. Oral morphine for cancer pain. In: The Cochrane Library, Issue 2, 2007. Chichester: John Wiley & Sons, Ltd. Search date 2002.

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