Visceral brain-body information transfer

Abstract

Organisms interact with their environments through various afferent (sensory) and efferent (motor) mechanisms. While the usual environment of interest has been external to the organism, the internal environment is also of fundamental importance. This article briefly reviews many of the interactive mechanisms between the brain and the visceral environment, along with identification of relevant brain structures and linkages related to these peripheral functions (particularly the hypothalamus). Afferent and efferent neural (autonomic nervous system) and chemical (endocrine, immune, and blood-brain barrier and circumventricular organs) pathways are described, and potential unifying principles (emotion and, especially, homeostasis, including allostasis and stress) are identified. The importance of bidirectional (afferent, efferent) communication is emphasized. These systems of visceral brain-body information transfer are major connections between the central nervous system and the body through which and by which many psychosomatic processes occur.