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. 2009 Jun;107(6):596-8.
doi: 10.1016/j.jbiosc.2009.01.023.

One-pot fermentation of pladienolide D by Streptomyces platensis expressing a heterologous cytochrome P450 gene

Kazuhiro Machida  1 , Yasuhide Aritoku, Toshio Tsuchida
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One-pot fermentation of pladienolide D by Streptomyces platensis expressing a heterologous cytochrome P450 gene

Kazuhiro Machida et al. J Biosci Bioeng. 2009 Jun.

Abstract

Pladienolide D is a 16-hydroxylated derivative of pladienolide B, produced by Streptomyces platensis. To facilitate the production of pladienolide D, the gene encoding a pladienolide B 16-hydroxylase from S. bungoensis was introduced into S. platensis. The recombinant produced pladienolide D at a production level comparable to that of pladienolide B.

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