Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Aug;48(8):867-71.
doi: 10.1093/rheumatology/kep101. Epub 2009 May 15.

Methotrexate, rheumatoid arthritis and infection risk: what is the evidence?

Andrew McLean-Tooke  1 , Catherine Aldridge, Sheila Waugh, Gavin P Spickett, Lesley Kay
Affiliations
Review

Methotrexate, rheumatoid arthritis and infection risk: what is the evidence?

Andrew McLean-Tooke et al. Rheumatology (Oxford). 2009 Aug.

Abstract

Low-dose MTX administered weekly remains a mainstay in the therapy of RA. There is a belief amongst rheumatologists that RA patients taking MTX have both an increased risk and severity of infection. Here we review the published data on the risks of infection associated with the use of MTX in patients with RA and make some recommendations for managing MTX in patients with infection.

PubMed Disclaimer

MeSH terms