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Comment
. 2009 May 15;15(10):3241-3.
doi: 10.1158/1078-0432.CCR-09-0434. Epub 2009 May 15.

Bringing DNA repair in tumors into focus

Christopher J Lord  1 , Alan Ashworth
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Bringing DNA repair in tumors into focus

Christopher J Lord et al. Clin Cancer Res. .

Abstract

Biomarkers are of crucial importance in optimizing cancer therapies. In this edition of Clinical Cancer Research, Bañuelos and colleagues assess H2AX phosphorylation as a predictive biomarker of response to DNA damaging agents. We discuss these results as well as the impact that double strand break repair biomarkers may have in cancer therapy.

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